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It’s springtime already?

Hello loyal readers (a list which includes, and may only be limited to, my dad, mom and the family dog that glances at the computer screen occasionally when they go online),

Sorry for the absence over the past few weeks. Things very hectic at work. But no worries – I’m planning to cheat make up for the lost time by backdating some observations made over the last month to make it look like I haven’t missed a thing. Thanks to my friends at Wordpress for building that functionality into my blogging software.

The good news is that since the start of the year I’ve had the joy of speaking with several interesting and relevant companies in this space. There is a ton of exciting stuff going on in the space, but event more moving pieces and question marks (chief among them are details around government stimulus, regulation, and reform, along with the eternal questions of “who will pay for this?” and “how will this integrate into the current health care system?” and of course “will it work?”; Letterman always asks a good question – I’d love to see his portfolio).

Thanks for checking in and stay tuned!

Greg

Are you kidding me? (#1)

Rep. Steven LaTourette, R- Ohio, uses a poster to describe proposed health care reform (Source: Somehow real life and not The Onion!)

This image sums up nicely the ‘mainstream’ opposition to proposed healthcare reform legislation. While the current Democratic Party-led reforms that have passed the House & Senate are either short-sighted and in need of a reboot, or should come clean that this is not the ‘be all end all’ solution Democrats claim it to becouldn’t the GOP do more than whine, complain and make ironic posters?

Third party, please.

Leno & NBC Do it Again

Sorry folks – this has nothing to do with the theme of this site, but I have to comment on this one. Who do Leno and NBC’s brass think they are? First they weasel Letterman out of Carson’s Tonight Show gig and now poor Conan? As the great philosopher Yogi Berra once said, “It’s deja vu all over again.” But thankfully, just about every media observer is ready to remind us of that. Here are the most hilarious “Leno bashing” moments to pop out of this controversy:

And for some of the most thoughtful analyses on this drama:

Besides the Leno criticism, the only other good things to come out of this are the infamous Late Show Super Bowl commercial and Conan’s Twitter page.

I typically aim to keep this site fairly positive, but this post is totally exempt from those protections. Want to lash out at Leno? Leave a comment. Let’s get this thing looking as hateful and decipherable as the comments section below a YouTube clip with a political message!

*Whereas most of us aim to be connoisseurs of fine wine, food, and art, my budget only permits me to hone my tastes for content delivered for free by iTunes.

Mind the Time Warp

The creative and thought-provoking arm-chair Nostradamus Richard Watson just took a stab at predicting the future of medicine, technology, society, and geopolitics over the next forty years. Interestingly, a lot of the topics discussed on this site showed up as current trends of note (e.g., medical tourism, consumer e-health, blurring of scientific discipline, telemedicine and online medical records). For a fun exercise, follow the ‘track lines’ out to the future from the points where these trends serve as a stops.

Just like real life, trips to the suburbs are long and disappointing.

I liked this one a lot – to the point of printing out a copy to share with one of my firm’s partners. I was joking when I told him this should serve as the bedrock of all our future investments – not really sure how we could profit by betting on the ruin of “optimism about the future” – but frankly, not all of these predictions are altogether unlikely (e.g., aged care & childcare robots by 2020, microscale health-botsall babies implanted with GPS and ID chips by 2035).

Click here to download the pdf, or visit the original posting on the futurist’s blogt. Enjoy. Have to say I’m looking for Harry Potter’s invisibility cloak in the next ten years.

Clinical Waste (or “I went ahead and threw rust proofing in with that physical”)

This is the second in a three part overview of the major contributors to “wasteful” healthcare spending in the US (estimated to be in the ballpark of $1 trillion annually). This installment cues up more in-depth discussions to come regarding complications which spring from poor decisions and policies at the time of treating disease (i.e., defensive medicine to avoid medical prosecution, medical errors, preventable readmissions, etc.).

Overview: The clinic is where the rubber meets the road in healthcare. This is where tests are run, surgeries go down, prescriptions are written, and where invaluable motivation, instructions and advice are dispensed by physicians. These are crucial touch-points that can lead to weak performance across the healthcare system or serve as sites of massive cost sinks if mismanaged. The waste in the clinic can be thought of in a couple ways: the extra spending due to defensive medicine (typically driven by rather unconscionable trial lawyers) and costs due to a lack of standards of care and sharing of best practices (where physician associations, hospital administrators, and government agencies are all responsible for their inability to generate the data or drive necessary to reach and share these standards).

Defensive Medicine

The biggest estimated source of waste that comes out of the process of treating patients springs from the widespread practice of “defensive medicine.” You can’t really blame physicians for testing the heck out of their patients – there is an army of trial lawyers in the US like this guy waiting to pounce on any potential physician misstep (real or otherwise) to line their pockets. Americans are known worldwide for a lawsuit-happy culture. I recall riding a tour bus out of London, listening to our guide tell us to “Buckle your seatbelts. I repeat – just for the Americans on the bus – buckle your seatbelts: I told you twice: now you can’t sue me!” In terms of medical malpractice, this stereotype is more than warranted. (By the way, this tour guide was the man. He shared some very funny Winston Churchill quotes. Is it just me, or are all British people genuinely hilarious. How do people that never laugh get to be so funny?)

The costs to the system here are threefold: costly and unnecessary tests, increased malpractice insurance costs, and actual settlement payouts resulting from bogus cases. These things all directly or indirectly raise the cost of healthcare. So why not take a shot a tort reform? Well, why not take quit your job, move to Hawaii and buy your own island paradise? Because of money: Congress (primarily Democratic lawmakers) has been bought by the trials lawyers that profit from medical malpractice suits, so much so that tort reform was effectively off the table during the current round of healthcare reform (see more here). All despite a Congressional Budget Office report that stated tort reform could save the federal government billions of dollars per year.

The solutions to unlock savings here can be approached through three waves:

  • Near-term (Government/ Voter-led solutions): State and federal governments should enact tort reform : i.e., demand special courts with medically knowledgeable judges making decisions (as opposed to juries with no expertise deciding cases on emotion over science), as well as caps on noneconomic damages like pain and suffering.
  • Medium-term (Government/ Physician-led solutions): Physician associations and government bodies should take the lead to gather extensive data and determine definitive answers regarding what treatments are most effective for specific patient sets and disease states. By providing proof of following these instructions, or a justifiable rationale for not doing so as set out in their guidelines, physicians could be better defended in the court of law.
  • Long-term (Startup/ Enterprise-led solutions). Medicine must evolve from art to a science: better tests and knowledge of the patient should dictate a more perfect, indisputable treatment that a physician can’t be faulted for performing. Advances in robotics and medication efficacy should also lower incidents of actual physician error where malpractice cases are warranted.

Other types of clinical waste

Whereas defensive medicine is more of a “woe-is-me” tale for doctors, the other types of clinical waste can largely be attributed to them and others in the medical profession – medical errors, poor coordination amongst they and their peers, treatment variations due to an inability to hold themselves to common standards, etc. I’d also argue that several doctors engage more generally in ‘over-testing’ and ‘over-treating’ at times, where instead of being defensive, they simply want to gain reimbursement for a quick though unnecessary task (which further highlights the perverse dilemma that US doctors make more from keeping patients sick than making them healthy).

There are quite a few smaller (relatively speaking!) buckets here, and each is worthy of its own dissection. But generally, solutions to these issues must include:

  • Agreed-upon standards of care (Government/ Physician-led solutions): As above, physician associations and government bodies should agree upon most effective treatments, and under what conditions one may override them. This should also include public health decisions which restrict the overuse of antibiotics and widespread adoption of techniques to avoid staph and other typical hospital-bred infections.
  • Better front-line care (Physician/Patient/Payer/Startup-led solutions): A stronger reliance on primary care physicians, along with better doctor-patient communication, can help prevent unnecessary ER visits and help ensure ideal ongoing treatment of chronic disease to avoid complications and hospital readmission. Interestingly, several startups (see here and here) are also tackling the task of connecting patients with primary care physicians via web- and phone-based systems in an attempt to increase the levels of communication and lower the cost and time required for a medical checkup.
  • Improved technology (Startup/ Enterprise-led solutions): More effective, targeted treatments can actually help physicians agree on obvious standards of care. And innovations in things like surgical robotics can cut down on the incidence of medical errors.

Diagnostic and Therapeutic Innovation

Something not included in the chart above given it would be impossible to size, but should technically be considered in this category, are cost savings possible through better treatments versus those common today. This would include better diagnostics to determine when expensive treatments are not necessary, better patient information (lifestyle factors, genomic details, and treatment histories) to better diagnose diseases and gauge treatment efficacy, and new low-cost, high-efficacy treatments that work better than current ones and deliver lower likelihoods of disease recurrence. These solutions will almost surely come from well-funded startups built around exciting new innovations most likely growing out of academic labs. The personalized medicine revolution and associated disruptive medical technologies fit this mold.

Next Steps: We’ll go in depth into each of the big sources of wastes and potential solutions, calling out more specialized considerations, and give some examples of trend-setting entrepreneurs.

Discussion Topic: What do you think about these problems and potential solutions? Are you or someone you know involved in startups operating in this space? Please feel free to let me know!

Boeing 787 Dreamliner: Sweet Looking Inside and Out

After continual set backs, Seattle’s*Chicago’s finest jet maker came through with the first successful test flight of its 787 Dreamliner last month. (By the way, if you want to see where the test craft is right now and details on its latest flights, click here). Around the time of the 787 virgin takeoff, I discussed some planned and hypothetical innovations to airliners to improve the flying experience. Well, Boeing appears to be targeting an improved in-flight experience with its new bird as a key way to differentiate itself from rival Airbus. And Wired got a first look inside the new jumbo jet just prior to Christmas. 

Welcome to the Boeing Ultra Lounge: where the security line out front is slightly LESS effecient than your typical NYC/Miami/LA club.

Some of our suggestions appear to be incorporated: cabin air should be more agreeable, and the design is meant to provide more open space to overcome the claustrophobic feel almost all of us get to some extent on an airplane. One interesting innovation is around lighting. Both the windows and the artificial lighting in the cabin will be tightly controlled to provide the best possible environment — conducive to sleep at night and gently waking up in the morning — showing the engineers at Boeing cosidered our circadian rhythms when designing the plane and did them a great favor. Though honestly, some shots of this advanced lighting don’t look too different from what Virgin America does today.

It’ll take a few flights with real passengers until we hear how well these changes pan out and what’s still missing (e.g., greater legroom, good food/ service, the ability to meet and socialize with passengers). That said, I applaud Boeing for making interior design changes which reflect an understanding of our bodies and an effort to minimize the toll taken on them when flying. 

*My hometown might have recently lost the Sonics but we haven’t forgotten about this travesty yet, either.

Behavioral Waste (or “Put out the cigarette, tubby”)

This is the first part of a three part overview of the major contributors to “wasteful” healthcare spending in the US (estimated to be in the ballpark of $1 trillion annually). This installment cues up more in-depth discussions to come regarding complications which spring from poor patient decision-making (i.e., smoking, unhealthy nutrition, failure to stick to prescription drug regimens, and alcohol abuse).

Overview: PriceWaterhouseCoopers estimates poor patient decision making necessitates ~$500B of otherwise unnecessary American health care spending each year. Obesity and smoking* are estimated to comprise a bulk of this figure (~$200B each), with non-adherence to prescription drug or physical therapy regimens contributing about $100B. Alcohol abuse makes up a much smaller figure (comparatively) at only $2B.

*For some reason, the smoking figure is given as a range of <$1B-$190B. That’s a pretty big range! My understanding is that the $200B figure reflects unrealized income due to possible higher cigarette taxes, where the ~$1B figure is the possible savings from a realistic reduction in smoking rates.

Issues at Play

Fighting behavioral problems are tricky: you’re basically hoping to override peoples’ cultural norms, comfort zones, and in some cases, addictions. Any government restrictions or attempts to influence behavior may be viewed as a threat to civil liberties. And finally special interests supporting these poor behaviors are massive, powerful, and resistant to anything that may encourage their customers to give up on them (just think of the restaurant chains, soda makers, massive grain processors, Big Tobacco, alcohol brewers, etc. – each group has a lot to lose and a very strong voice with lawmakers).

However, the war on tobacco is a great example of how concerted efforts can have a massive and positive impact on personal behavior. Smoking rates are way down in the US over the past few decades, with a lot of that likely driven by government steps to discourage smoking. Drugs like Chantix and nicotine replacement therapies and counseling are widely available. And start-ups are even at work designing tools to support positive behaviors. It feels like learnings from the anti-smoking revolution could be applied more widely to fight obesity and alcohol abuse, and to some extent, help encourage patients to adhere to trying medical treatments.

Conflict with the American Way?

Treating problems stemming from poor behavior lead to one of the most fundamental points of friction in the US surrounding the adoption of a more socialized form of medicine: should people leading healthy lifestyles have to subsidize the high healthcare costs of those leading unhealthy ones? Jon Stewart recently interviewed Cabinet woman Kathleen Sebelius, the head of the Department of Health and Human Services and former Kansas Governor. He pointed out that he’s in the top bucket of earners and may have to pay an additional income tax to offset the cost of expanded patient coverage. As a result, he joked, “Can I then stop poor people from smoking and eating ice cream? If I see them on the subway can I say ‘Hey dude – you’re costing me money’?’” While responsibility for one’s own decisions is paramount, there is a fine line between denying healthcare and demanding one pay for their own poor decisions: the CEO of Whole Foods found this out the hard way when he was roasted by his left-leaning customers for his apparent support of Republican obstructionism of healthcare reform after authoring a piece suggesting we should hold people accountable for their nutrition. Moreover, who is to say that someone more genetically inclined to be diagnosed with diabetes or heart disease should have to bear the cost of their own treatments when the bar to getting their disease was lower than those of others?

Some have called for taxes on unhealthy snacks like sugary soda. Indeed, such surtaxes are in place and expanding in the world of tobacco. And the taxes may be working. It’s arguable as to whether the drop in US smoking rates are due to better knowledge of the longer-term repercussions of tobacco use, a media-led blasphemication of Big Tobacco, or higher prices per pack. But something is clearly having an impact.

Healthcare + Productivity Drain

Finally, it’s important to note that other costs not shown here impact the economy more broadly – PWC says other costs due to “lost productivity, absenteeism, and presenteeism, can be three to four times higher.” Ironically, once the economy gets moving again, we’ll need as many people working as possible to generate tax income to pay off the Baby Boomers drawing from Social Security and Medicare. It’ll be imperative that we keep our workforce healthy and productive to do just that, and thus ensuring people make the right health decisions will be even more important.

 What Can Be Done?

Generally speaking I can think of a few ways to tackle these problems:

  • Education (Government/ Parent-led solutions): As early as possible, teach students about the importance of nutrition, good health, and obeying doctor’s orders. Reinforce these messages over time and through as many channels as possible.
  • Disclosures at Point of Sale (Government-led solutions): Place notices, like the surgeon general warnings on cigarettes packs, on packaging or menus that outline the risk of alcohol and Calorie-rich food. Moreover, governments can force restaurants to display nutritional data like Calorie counts on their menus (they are increasingly doing so, to some effect, in pioneering cities like NYC).
  • Taxes (Government-led solutions): Tax unhealthy vices (e.g., cigarettes, alcohol, or fast/ sugary food) to discourage their consumption, fund educational programs explaining why they’re so bad, and pay for the increased healthcare costs they cause.
  • Drugs (Enterprise/ Startup-led solutions): A slew of biopharma pipeline drugs aim to get people to quit smoking, abusing alcohol and overeating (though unfortunately are often associated with the adverse effect of depression). It’s hard to think of these drugs as ‘disruptive,’ as drug companies typically find a way to squeeze out as much profit as possible to recoup R&D costs, and it’s hard to equate smoking quit rates or lower Calorie consumption during a clinical trial to lifetime healthcare cost savings. But if these drugs work well at getting people to live healthier they could easily be cost-effective to prescribe. Let’s just hope anyone prescribed these drugs actually take them (as non-adherence is the one behavioral issue you obviously can’t design a drug to treat)!
  • Personal Behavior Support Tools (Startup/ Enterprise-led solutions): Here’s where entrepreneurs are best suited to get into the mix. Imagine mobile apps that remind you to take prescription pills, tell you how many Calories are in your lunch options, track what you ended up eating each day, or measure your weekly workout performance. Or social networking tools which encourage you to challenge friends and family to live healthy. Given entrepreneurs in this realm can sell directly to patients, but provide value to healthcare payers and employers, their ability to monetize their products and services are strong.
  • Just Live Healthy (Patient-led solution): The old fashioned way of staying healthy. Putting this on here because if it worked for my grandparents’ generation it theoretically is still effective.

Next Steps: We’ll go in depth into each of the big sources of wastes and potential solutions, calling out more specialized considerations, and give some examples of trend-setting entrepreneurs.

Discussion Topic: What do you think about these problems and potential solutions? Are you or someone you know involved in startups operating in this space? Please feel free to comment or let me know.

Interesting trends in spending on healthcare vs. other basic necessities

Here are some old but interesting data exhibits taken from Deloitte’s 2006 report “The Catalyst for Health Care Reform” (though original source of the analysis appears to the Bureau of Economic Analysis). Since 1950, spending per $1000 of Americans’ discretionary income has decreased for food and clothing, remained constant for housing prices, and increased considerably for healthcare. 

Trends in healthcare spending undo productivity gains elsewhere

I’m somewhat curious about a couple things:

  1. How much longer can this continue?
    The trend in increased healthcare spending is alarming, especially as productivity gains start to level off in other sectors and certain areas of spending not shown (e.g., technology and telecom connectivity) become increasingly important. Where will new wealth come from to support healthcare costs?  
  2. Is the drop in food prices actually contributing to the increase in healthcare spending? (And if so, how much is it driving?)
    As foreshadowed in a recent post, patients’ behavioral decisions which lead to health issues like diabetes squeeze hundreds of billions of dollars out of our healthcare system each year. It’s great that the fast food revolution provides cheap and tasty food very quickly. But how much of the savings leak out when it comes time to repair the damage it wracks on our cardiovascular or endocrine systems?

This analysis is further proof of just how badly healthcare costs are spiraling out of control in the US and how quickly we’ll need to act to counteract them.

Finally, to those who watched football today: what a day! Some good games and a lot of playoff implications. As far as who I want in the Big Game, I’m going to go with my heart and say: “Anyone but the Pats!” And of course, my Seahawks will have to wait until next season (when hopefully the offensive line will finally gel and Justin Forsett becomes our featured back).

Ambitious news (featuring T-Pain)

In the face of the continued healthcare debate on Capitol Hill, I’d like to launch a project on this site where we explore ways in which we can reduce healthcare spending and improve quality by eliminating waste and inefficiency. While politicians claim to be lowering cost through winning concessions from biopharma, medical device, and insurance companies, this may (arguably) stifle technological and business model innovation in the long run. Even if it doesn’t, this reform attempt still only attacks profiteering in one part of the system – it leaves many bastions of wasted spending untouched.

The main purpose of these bills is in fact to force people to get insurance (pressuring them with the carrot/ stick combo of tax credits or the threat of jail time and requirements that their employers to provide it for them). If anything, a new law requiring increased insurance coverage without a public option will be a boon to US insurance companies, partially offset by the legislation’s requirement that they no longer drop coverage or raise prices for sick people or deny coverage to people with preexisting conditions. The same ‘business as usual’ waste will now be extended across almost all Americans.

It’s great that more Americans are likely to be covered by health insurance in the years ahead, but it seems sensible to think about ways that we can make the system truly more cost-effective – an area where our healthcare system stinks. While switching to a single payer/ government-run system could likely do more than anything to encourage cost savings, it’s unlikely to happen soon given the divisiveness of the issue.

My idea is that we’ll approach the big buckets of waste in the healthcare system over time and suggest solutions. The initial framework that makes sense to me for organizing this project is Price Waterhouse Coopers’ categorization of health care waste in “the price of excess.” They outline three major buckets of waste, with the following sub-breakdowns :

Annual wasted spending in health care (Source: PWC)

I wouldn’t put too much weight into the actual numbers they’ve calculated here (e.g., jump into their document and check out the range on the smoking figure…), but generally speaking I think they help prioritize the biggest causes of wasted spending in the system.

 Changes to the healthcare system will not be easy. Any innovation will undoubtedly stumble due to the following:

  • Regulation: Healthcare is regulated, as it should be, but this means certain businesses can’t get off the ground without appropriate spending on approvals, certifications, etc. Compliance with reporting guidelines, inspections and other laws also make healthcare businesses costly to run.
  • Public Policy: Healthcare and medical research policies are divisive (e.g., single payer systems, stem cell research, cloning, genetic code processing, etc.). As the current debate illustrates, if political winds change, entire business opportunities can arise or vanish overnight.
  • Special Interests: Some doctors prefer the current wasteful setup that pays them for any surgery or test they provide (as opposed to paying others for keeping patients healthy in the first place), trial lawyers certainly appreciate the chance to sue the pants off the same doctors in instances where they didn’t test for every potential complication a patient could have had and missed an unlikely disease state, biopharma loves the ability to market directly to consumers, and insurance companies love to exist. Other groups are enablers of bad health (just follow the unnatural fatty food chain from Monsanto to ADM to General Mills to McDonald’s), and will push anything that infringes on their ability to maximize profits by fattening our stomachs and hardening our arteries. All of these groups will need to give ground to reform our healthcare mess, and pushing them around will not be easy.

I invite you to send me business plans, concepts, or vague ideas you have to tackle these issues (greg@biorebellion.com). Or just feel free to post comments on the site. From time to time I’ll target a specific bucket of waste and summarize my own ideas, companies I know to be targeting the space, and will try to involve experts’ opinions in the space. Meanwhile, I’ll keep a repository of our findings in a new location on the website.  I’m looking forward to this and think it should be a lot of fun.

By the way, for something only minimally related to the healthcare debate, but is hilarious and features the world’s greatest mobile phone and app, check this out.

A Very Merry BioRebellion Christmas!

Merry Christmas, everyone! Hope you enjoyed your time off with family, giving/ receiving gifts and some sort of puppet people playing basketball. The year is (thankfully) almost over, but there have been some huge and divisive developments in American healthcare policy in 2009 that are likely to shape the next decade of medicine and beyond. The jury is out on whether the healthcare changes, which are very likely to pass into law next month, will be a net positive on the cost and quality of our healthcare. It will take several years to get at the answer.

I've asked Santa for a new decade since X-mas 2001...and he finally delivered.

Luckily, innovative solutions to the problems persistent in our healthcare system continue to coalesce, and the attention placed on such solutions has never been so motivated or focused. I’ll do my best to stay on top of such innovations — as well as some other interesting trends in industries outside healthcare that promise to apply our understanding of the life sciences to improve things. But given the emphasis placed on healthcare in the last several months, you can expect a lot of attention to be devoted to that topic.  

Merry Christmas and Happy New Year. Here’s to a great 2010 and beyond!  

-Greg